2P-OOI Prevention and Therapeutic Effects on Acute and Chronic Inflammation Model at Water-Drinking Agaro-Oligosaccharides NISHIYAMA Eiji, DEGUCHI Juju, FUJII Kinya, SAGAWA Hiroaki, MIZUTANI Shigetoshi, KATO Ikunoshin , Takarra Shuzo Biotec. Res. Lab.) (Purpose) We have reported that agaro-oligosaccharides show suppression effects for cancer cell growth in vitro to suppress NO generation of macrophages due to LPS stimulation 1),2).3). This time, we studied to confirm the results in vivo using an experimental model with mice. (Method) ( 1) Endotoxin shock was prepared by giving LPS through intraperitoneal administration. (2) Fulminant hepatic failure was prepared by galactosamine and small amount of LPS simultaneously through intraperitoneal administration. (3) As a disease model for arthritis rheumatoides, II type of collagen arthritis was prepared. We have studied effects at water-drinking agaro-oligosaccharides. (Results) (1),(2) For mice previously administrated with agaro-oligosaccharides by water-drinking, fatality due to endotoxin shock and fulminant hepatic failure was significantly improved as weIl as suppression of blood concentration of TNF-alpha, inflammatory cytokine. (3) ln the chronic arthritis model, agaro-oligosaccharides show not only preventive effect due to water drinking but also curative effects. (Conclusion) Above results show that agaro-oligosaccharides if taken are expected to improve inflammatory diseases such as arthritis rheumatoid in addition to anti-ca ncer effect 4). 1) 20th Cabohitrate Syposium proceedings 2) 57th Japan Cancer Society General Congress proceedings 3) 71st Japan bio-chemisty Society General Congress proeedings 4) 58th Japan Cancer Society General Congress proceedings